Brochure:
Innovative tools for drug discovery
Conference Posters:
2014 AACR Annual Meeting San Diego “Trastuzumab distribution following bevacizumab”
2014 AACR Annual Meeting San Diego "Camptothecins: tissue dynamics and implications for therapy"
2009 EORTC-NCI-AACR Boston "Targeting the tumour microenvironment: anti-vascular effects of the hypoxic cytotoxin tirapazamine"
2008 EORTC-NCI-AACR Geneva “Tight junctions as a limit to Herceptin Penetration?”
2007 EORTC-NCI-AACR San Francisco “Classification of anticancer drugs based on tissue penetration using a novel in vitro screening assay”
2006 EORTC-NCI-AACR Prague “Extravascular penetration of taxanes limit their efficacy”
2005 AACR Anaheim “Tirapazamine Causes Vascular Dysfunction”
2004 EORTC-NCI-AACR Geneva “In vitro screening of anticancer drug penetration into tumour tissue”
2003 EORTC-NCI-AACR Boston “In vitro screening of drugs based on their ability to diffuse through tumour tissue”
Publications:
Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts.
J.H.E. Baker, K.E. Lindquist, L.A. Huxham, A.H. Kyle, J.T. Sy and A.I. Minchinton
Clin Cancer Res 2008;14(7):2171-79.
Limited Tissue Penetration of Taxanes: A Mechanism for Resistance in Solid Tumors.
Kyle AH, Huxham LA, Yeoman DM and Minchinton AI
Clin Cancer Res 2007;13(9):2804-10.
Drug penetration in solid tumours.
Minchinton AI and Tannock IF.
Nat Rev Cancer 2006;6:583-592.
Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts.
Huxham LA, Kyle AH, Baker JH, McNicol KL and Minchinton AI.
Radiother Oncol 2006;78:138-145.
Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay.
Baker JH, Huxham LA, Kyle AH, Lam KK and Minchinton AI.
Microvasc Res 2006;71:69-75.
Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture.
Kyle AH, Huxham LA, Chiam AS, Sim DH and Minchinton AI.
Cancer Res 2004;64:6304-6309.
Microregional effects of gemcitabine in HCT-116 xenografts.
Huxham LA, Kyle AH, Baker JH, Nykilchuk LK and Minchinton AI.
Cancer Res 2004;64:6537-6541.
Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent.
Kyle AH, Huxham LA, Baker JH, Burston HE and Minchinton AI.
Cancer Res 2003;63:5707-5711.
Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model.
Kyle AH and Minchinton AI.
Cancer Chemother Pharmacol 1999;43:213-220.
Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy.
Kyle AH, Chan CT and Minchinton AI.
Biophys J 1999;76:2640-2648.
Multilayers of cells growing on a permeable support. An in vitro tumour model.
Minchinton AI, Wendt KR, Clow KA and Fryer KH.
Acta Oncol 1997;36:13-16.
