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Conference Posters



Innovative tools for drug discovery

Conference Posters:

2014 AACR Annual Meeting San Diego “Trastuzumab distribution following bevacizumab”

2014 AACR Annual Meeting San Diego "Camptothecins: tissue dynamics and implications for therapy"

2009 EORTC-NCI-AACR Boston "Targeting the tumour microenvironment: anti-vascular effects of the hypoxic cytotoxin tirapazamine"

2008 EORTC-NCI-AACR Geneva “Tight junctions as a limit to Herceptin Penetration?”

2007 EORTC-NCI-AACR San Francisco “Classification of anticancer drugs based on tissue penetration using a novel in vitro screening assay”

2006 EORTC-NCI-AACR Prague “Extravascular penetration of taxanes limit their efficacy”

2005 AACR Anaheim “Tirapazamine Causes Vascular Dysfunction”

2004 EORTC-NCI-AACR Geneva “In vitro screening of anticancer drug penetration into tumour tissue”

2003 EORTC-NCI-AACR Boston “In vitro screening of drugs based on their ability to diffuse through tumour tissue”


Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts.
J.H.E. Baker, K.E. Lindquist, L.A. Huxham, A.H. Kyle, J.T. Sy and A.I. Minchinton
Clin Cancer Res 2008;14(7):2171-79.

Limited Tissue Penetration of Taxanes: A Mechanism for Resistance in Solid Tumors.
Kyle AH, Huxham LA, Yeoman DM and Minchinton AI
Clin Cancer Res 2007;13(9):2804-10.

Drug penetration in solid tumours.
Minchinton AI and Tannock IF.
Nat Rev Cancer 2006;6:583-592.

Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts.
Huxham LA, Kyle AH, Baker JH, McNicol KL and Minchinton AI.
Radiother Oncol 2006;78:138-145.

Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay.
Baker JH, Huxham LA, Kyle AH, Lam KK and Minchinton AI.
Microvasc Res 2006;71:69-75.

Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture.
Kyle AH, Huxham LA, Chiam AS, Sim DH and Minchinton AI.
Cancer Res 2004;64:6304-6309.

Microregional effects of gemcitabine in HCT-116 xenografts.
Huxham LA, Kyle AH, Baker JH, Nykilchuk LK and Minchinton AI.
Cancer Res 2004;64:6537-6541.

Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent.
Kyle AH, Huxham LA, Baker JH, Burston HE and Minchinton AI.
Cancer Res 2003;63:5707-5711.

Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model.
Kyle AH and Minchinton AI.
Cancer Chemother Pharmacol 1999;43:213-220.

Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy.
Kyle AH, Chan CT and Minchinton AI.
Biophys J 1999;76:2640-2648.

Multilayers of cells growing on a permeable support. An in vitro tumour model.
Minchinton AI, Wendt KR, Clow KA and Fryer KH.
Acta Oncol 1997;36:13-16.